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Follistatin (FST) is a secreted glycoprotein that was first identified as a follicle-stimulating hormone inhibiting substance in ovarian follicular fluid (1, 2). Human Follistatin cDNA encodes a 344 amino acid (aa) protein with a 29 aa signal sequence, an N-terminal atypical TGF binding domain, three Follistatin domains that contain EGF-like and kazal-like motifs, and a highly acidic C-terminal tail. Follistatin is a secreted protein that binds to ligands of the TGF-Beta family and regulates their activity by inhibiting their access to signaling receptors. It was originally discovered as activin antagonists whose activity suppresses expression and secretion of the pituitary hormone FSH (follicle stimulating hormone). In addition to being a natural antagonist, follistatin can inhibit the activity of other TGF-Beta ligands including BMP-2,-4,-6,-7, Myostatin, GDF-11, and TGF-Beta1. Follistatin is expressed in the pituitary, ovaries, decidual cells of the endometrium, and in some other tissues. Recombinant human Follistatin is a 37.8 kDa protein containing 344 amino acids.
Function:
1 . Follistatin-344 significantly increases the muscle mass and strength (by blocking the action of myostatin) - supports hyperplasia (new muscle cells), and active hypertrophy (enlargement of muscle cells).
2 . Follistatin-344 has potent anabolic effects (without concomitant androgenic activity), use Follistatin-344 leads to muscle hyperplasia (growth of new muscle fibers) and active hypertrophy (increasing the volume of existing muscle fibers).
3 . Follistatin-344 has the ability to maintain a strong athletes as massive as in muscle, although longer sport.
4 . Follistatin-344 significantly improves performance.
5 . Follistatin-344 has potent anti-aging effect, significantly affects the rejuvenation of all tissues in the body.
6 . Follistatin-344 promotes the burning of body fat.
